Trends in Pancreatic Cancer Related Mortality: A Retrospective Analysis using CDC WONDER Database

Nikhil Duseja; Kanz Ul Eman Maryam; Ghufran Azam; Muhammad Uzair; Danish Ali Ashraf; Sheheryar Ibrahim; Fatima kaleem Ahmed; Inzamam ul Haq; Sabah Rizvi; Aiman Murtaza; Warda Mushtaq Khosa; Ali Raza; Hasnain Farhan; Maha Mushtaq Khosa

doi:10.61797/ijetit.v5i2.405

Nikhil Duseja Department of Internal Medicine, Karachi Medical and Dental college,Karachi.
Kanz Ul Eman Maryam Department of Internal Medicine, Foundation University Medical College, Islamabad.
Ghufran Azam Department of Internal Medicine, Liaquat University of medical and health sciences
Muhammad Uzair Department of Internal Medicine, Ziauddin Medical University, Karachi.
Danish Ali Ashraf Department of Internal Medicine, Foundation University Medical College, Islamabad.
Sheheryar Ibrahim Department of Internal Medicine, Ziauddin Medical University, Karachi.
Fatima kaleem Ahmed Department of Internal Medicine, Bahria University of Medical and Dental College.
Inzamam ul Haq Department of Internal Medicine, Sheikh Mohamed bin Zayed Al-Nayan Instititue of Cardiology, Quetta.
Sabah Rizvi Department of Internal Medicine, Liaquat National Medical College, Karachi.
Aiman Murtaza Department of Internal Medicine, Quaid e Azam Medical college, Bhawalpur, PK
Warda Mushtaq Khosa Department of Internal Medicine, Quetta Instititue of Medical Sciences, Quetta, Pk.
Ali Raza Department of Internal Medicine, Ziauddin Medical University, Karachi.
Hasnain Farhan Department of Internal Medicine, Ziaudin Medical University, Karachi.
Maha Mushtaq Khosa Department of Internal Medicine, Quetta Instititue of Medical Sciences, Quetta, Pk.

DOI: https://doi.org/10.61797/ijetit.v5i2.405

Keywords: Pancreatic cancer, Mortality, Gender, Regional, Trends

Abstract

Background: Pancreatic cancer is 8th most prevalent cancer in the United States with a very high mortality rate. Understanding the epidemiology of Pancreatic cancer is important in identifying the causes and developing preventive strategies.

Methodology: Data from the death certificates spanning from 1999-2020, sourced from CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) was analyzed. To quantify national annual trends in pancreatic cancer-related mortality, the Joinpoint Regression Program was used to determine the annual percent change (APC) with 95% CI in age-adjusted mortality rates (AAMRs) per 100,000 people for all ages stratified by year, gender and regions.

Results: Pancreatic neoplasm claimed about 847,589 lives across all age groups in the US from 1999-2000. The AAMR for pancreatic cancer peaked at 2020 with 11.7 [APC 0.2275 95% CI: 11.6-11.8]. The AAMR for pancreatic cancer-related deaths was 11(95%CI: 10.9=11.1) in 2003 and it increased to 11.3(95%CI: 11.2-11.3) in 2006 (APC 0.87* 95%CI: 11.2-11.4). Men had consistently higher AAMRs than women across all age groups throughout the study period of 1999-2000 (overall AAMR men: 13.2 (95% CI: 13.1-13.2); overall AAMR women: 9.9 (95% CI: 9.9-10)). Geographically; the lowest mortality was displayed by the Western regions (AAMR 10.5, 95% CI: 10.2-10.7), followed by Southern (AAMR 11.1, 95%CI: 10.9-11.4), followed by Midwestern (AAMR 11.7, 95%CI: 10.9 -11.4), followed by Northeast region (AAMR 11.9, 95%CI: 11.6-12.1).

Conclusion: We observed an overall annual increase in mortality trends related to pancreatic cancer especially in men and certain regions like Northeast region of the United States. These results emphasize the immediate necessity for a comprehensive strategy to address this lethal illness, encompassing breakthroughs in medical research, focused public health initiatives, and extensive governmental reforms.